Synthesis, characterization and catalytic evaluation of NiFe2O4@SiO2@glucose amine for the synthesis of novel derivatives of triazoles

Triazoles and their derivatives are of great importance in medicinal chemistry and can be used for the synthesis of numerous heterocyclic compounds with different biological activities such as antiviral, antibacterial, antifungal, antituberculosis, anticonvulsant, antidepressant, anti-inflammatory and anticancer activities. They have been reported to be inhibitors of glycogen synthase kinase-3, antagonists of GABA receptors, agonists of muscarine receptors, be neuroleptic, and these compounds also show anti-HIV-1, cytotoxic, antihistaminic, and antiproliferative activities [1]. Thus, the design and synthesis of novel triazole derivatives are the prospective direction of medicinal chemistry for the scientists working in this field.In continuation of our previous work [2], herein, we specifically address the multicomponent synthesis of triazoles using NiFe2O4@SiO2-propyl@glucose amine magnetic nanoparticle as catalyst .The prepared nanocatalyst was characterized using Fourier Transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA) and a vibrating sample magnetometer (VSM). All of organic compounds are new and characterized by IR, 1H NMR, 13 C NMR, Mass and elemental analysis.

Keywords:

Multicomponent reactions , triazoles , nanocatalyst