Synthesis of 5-substituted 1H-tetrazoles by clean cabbage like silver crystals

Tetrazoles are synthetic heterocyclic compounds having one carbon and four nitrogen atoms in a five-membered ring.1 They have widespread applications in materials science,2 and medicinal chemistry.3 Moreover, they can be served as lipophilic spacers and carboxylic acid substitutes.4 One of the most significant aims of tetrazoles chemistry is searching for a new synthetic method as well as improvement of previous procedures. The most versatile used method for the syntheses of 5-substituted 1H-tetrazoles is [3+2] cycloaddition of nitriles and azide anion in the presence of various catalysts and solvent conditions. Several organic, inorganic, homogeneous, and heterogeneous catalysts have been used for this purpose. Herein we introduced our process as a highly efficient method for conversion of aldehydes into the corresponding 5-substituted 1H-tetrazoles using clean cabbage like silver crystals as reusable catalyst (Fig.1).

Keywords:

Multicomponent reactions , 5-Substituted 1H-tetrazoles , Silver crystals , Catalyst.