Survey tri-components reaction of trifluoroacethymidoyl chloride, isocyanide and quinoline

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

ISOC27_339

تاریخ نمایه سازی: 19 اسفند 1399

Abstract:

Amongst heterocyclic compounds, nitrogen heterocycles are very important. pyrimido[5,1-a]isoquinolines, pyrimido[5,1-a]pyridines and pyrimido[5,1-a]quinolines as the most stable, nitrogen-riched heterocyclic compounds show high levels of biological activities.1 Nitrogen heterocyclic compounds contain trifluoromethyl substitute are very interesting due to the strong electron-withdrawing effect of the CF3 group which contributes to a number of biologically properties.2 These compounds are interesting as physiologically active agents.3 Herein we wish to report, a highly efficient method for synthesis of triflouromethylated pyrimido[5,1-a]isoquinolines 4, pyrimido[5,1-a]pyridines 5 and pyrimido[5,1-a]quinolines 6 derivatives from reaction of N-alkyl-benzimidoyl chlorides 1 (prepared in situ from the corresponding benzylamine, triphenylphosphine and CCl4), with isoquinoline 3a/ pyridine 3b or quinolone 3c and cyclohexylisocyanide 2 in present of base under reflux conditions in dry CH3CN (Fig. 1).

Authors

Najmeh Zeinali

Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran

Ali Darehkordi

Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran

Elham Kazemi

Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran