One-pot, three-component and green synthesis of diversely substituted N-aryl pyrroles

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

ISOC27_346

تاریخ نمایه سازی: 19 اسفند 1399

Abstract:

Today, green chemistry approaches have received considerable attention from chemists because of the reduction in by-products, produced waste and energy cost.1 Because of the significant role of ionic liquids in green chemistry as a consequence of their unique properties such as offering enhanced rate,2 ease of product recovery,3 catalyst immobilization,4 and recycling,5 extraordinary consideration has been devoted to promoting organic reactions in ionic liquid media.N-aryl pyrrole–containing compounds are an important class of N-heterocycles that are frequently found in many natural products,6 and exhibit a wide array of biological activities such as antimycobacterial,7 anticancer,8 and anti-HIV 9 activities. Herein, we report the synthesis of substituted N-aryl pyrroles 4 from the reaction between nitroalkenes, 1,3-dicarbonyl compounds, and primary aromatic amines using [Et3NH][HSO4] ionic liquid under solvent-free conditions (Fig. 1).

Authors

Mahboobeh Zahedifar

Department of Chemistry, faculty of science University of Jiroft, Jiroft, ۷۸۶۷۱۶۱۱۶۷, Iran

Behjat Pouramiri

Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran