Mina Khedmati - Faculty of Chemistry, Ghadr Institute of Higher Education, Guilan, Rasht, Iran
Bahman Sharifzadeh - Assistant Prof. Department of Engineering Science, Faculty of Engineering - East Guilan, University of Guilan, Guilan, Roodsar, Iran
Cobra Azimi - Ph.D. of Organic Chemistry, University of Guilan, Rasht, Iran

Multicomponent reactions (MCRs) combine three or more reactants in a single operation to afford an adduct with a minimum loss of atoms.1 The development of multi-component reaction 2 protocols for the synthesis of heterocyclic compounds has attracted significant interest from pharmaceutical groups. The Ugi four-component reaction (Ugi-4CR) is useful isocyanide- based MCRs that allow easy access to structurally varied and complex intermediates or scaffolds.3 The use of water as a solvent for organic transformations offers several “green chemistry” benefits.4-5 The product is formed by the synthesis of di-amid from cyclohexyl isocyanide 1, aldehyde 2, benzylamine 3, ibuprofen 4 in room temperature and water used as solvent. The structures are determined on the basis of their mass spectrum 13CNMR, 1H-NMR, and IR spectroscopic data.

Multicomponent reaction, Ugi, Green chemistry, Isocyanides, Di-amide, Ibuprofen