Magnetic nanoparticle drug delivery systems for targeting tumor based on PEI -FA bonded Fe3O4@SiO2@CPS nanoparticles

Magnetite Fe3O4 nanoparticles have widespread applications in the magnetic bioseparation,1 drug delivery,2, 3 and magnetic resonance imaging,4 especially in targeted drugs. Herein we developed a targeted anticancer drug delivery system based on folate-conjugated rattle-typeFe3O4@SiO2@CPS (3-chloropropyltriethoxysilian) hollow mesoporous spheres combining receptor-mediated targeting and magnetic targeting. Polyethylenimin -folic acid (FA) ligands were successfully grafted onto rattle-type Fe3O4@SiO2 hollow mesoporous spheres via amide reaction (Fig.1). Doxorubicin (DOX) an anticancer drug, was introduced into nanocarier spheres. The nanoparticles were characterized using various scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM).

Keywords:

Targeted drug delivery , Anti-cancer , Nanocarriers , Magnetic nanoparticle