Preparation of Chitosan and Alginate Nano-Fibers in Delivery of Curcumin by Electrospinning

Electrospinning has been used to generate nanofibers via an electrically charged jet of the polymer solution. This process is established on a spinning technique, using electrostatic forces to produce fine fibers from polymer solutions. Nanofibers drug delivery systems have been developed for improving the therapeutic effects and to reduce the side effects of anti-cancer drugs. Curcumin is a natural compound extracted from the roots of Curcuma Longa L. and its cytotoxic properties were studied. Nanofibers of Chitosan (CS) alginate (ALG) loaded curcumin(CUR) were prepared by the electrospinning method. Their morphology was evaluated by Scanning Electron Microscopy. The drug loading and release rate of nanofibers (CS/ALG) were studied. Drug release rate dependence on pH and temperature. In vitro release rate was performed in acidic pH. The 56% of cells (the colorectal cell line HT-29) survived under MTT cytotoxic method after 72 hours exposed of (CS/ALG+ CUR) nanofibers.

Keywords:

Chitosan , Nanofibers , Electrospinning , curcumin , Anticancer