The synthesis of 2,3-dihydroquinazolinones in the presence of nano-biocatalyst

2,3-Dihydroquinazolin-4(1H)-ones are an important class of nitrogen-containing heterocyclic compounds which have attracted more attention in medicinal chemistry. They have extensive roles as key building units in the preparation of valuable drugs such as anticonvulsant,1 antitumor,2 and anticancer.3Heterogeneous catalysts have been widely used in industrial and green chemistry because of their unique advantages such as easy separation from reaction media by simple filtration.4 Nano-ovalbumin is a globular, biocompatible, non-toxic and biodegradable phosphoglyco protein that has been recently used as a heterogeneous and eco-friendly catalyst.5We have synthesized 2,3-dihydroquinazolin-4(1H)-ones via condensation of 2-aminobenzamide and different aldehydes in the presence of nano-ovalbumin as a retrievable, metal-free and heterogeneous biocatalyst and in reflux (EtOH/H2O) conditions (Fig. 1).

Keywords:

Biocatalyst , 2 , 3-Dihydroquinazolinone , Eco-friendly catalyst , Nano-ovalbumin