Synthesis of 5-(3-benzylbenzo[d]thiazol-2(3H)ylidene)1,3-dimethylpyrimidine-2,4,6(1H, 3H, 5H)-trion

Benzothiazole ring belongs to the privileged scaffolds in modern medicinal chemistry.1 Benzothiazole and its derivatives are extensively heterocyclics due to their wide spectrum of bioactivities. Among them, the imidazobenzothiazoles are pharmacologically important because of their anti-inflammatory, antifungal, antitumor, antibacterial, and other properties. 2, 3 On the other hand, benzothiazoles have industrial applications including serve as light-emitting materials in optical devices, fluorescent, electroluminescent, liquid crystal, semiconductor, optical sensors and photovoltaic cells.4,5 In this work, synthesis of 5-(3-benzylbenzo[d]thiazol-2(3H)ylidene)1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trion is repor- ted from reaction of 2-chlorobenzothiazole 1, 1,3-dimethylbarbitoric acid 2 in the presence of benzybromide 3 in good yield.

Keywords:

2-Chlorobenzothiazole , Benzyl bromide , 1 , 3-Dimethyl barbituricacid , Formation of C=C.