Synthesis of some heterocyclic compounds bearing nitrogen atom using magnetite nanoparticles supported on γ-Al2O3/BF3/Fe3O4 under different conditions

In recent years, using nano-size solid acids in chemical reactions have been known as a principle in the development of green chemistry. The efficiency of heterogeneous and magnetite catalysts can be enhanced using nanosized catalysts because of their extremely small size and large surface to volume ratio and act as a bridge between homogeneous and heterogeneous catalysts.1 On the other side, heterocyclic compounds containing nitrogen have received much attention for their biological activities and the extensive application in both pharmaceutical and industrial researches.2 Therefore, the widespread application of solid acids, and magnetite nanoparticles structural and practical diversity of heterocyclic compounds containing N atom have prompted us to employ the novel and eco-friendly methods for the synthesis of heterocyclic compounds including: Indazolo-phthalazine-triones3, 2,3-dihydro-1H-perimidines4, Quinazolines5, and Dihydropyrazines6 using nano γ-Al2O3/BF3/Fe3O4 as a green magnetite catalyst under different conditions. Firstly, nano γ-Al2O3/BF3/Fe3O4 were prepared (Scheme 1). Its structure and properties were characterized through the conventional methods of determining materials such as FE-SEM, TEM, FT-IR, XRD, BET, VSM, and TGA. Then, the catalyst was used in the synthesis of some heterocyclic compounds bearing N atom. The obtained products have been characterized by FTIR, 1H NMR, and 13C NMR spectroscopy.

Keywords:

Multicomponent reactions , Green chemistry , magnetite nanoparticle , γ-Al2O3/BF3