Design and preparation of easily recycled Fe3O4@SiO2@layered Zinc hydroxide as a highly efficient heterogeneous catalyst in Aza-Michael Addition

The synthesis of tetrazoles has a special interest because of their broad biological activities.1 The conjugate addition of heteroatom nucleophiles to α, β-unsaturated carbonyl compounds (i.e., Michael reaction) is one of the most important tools in organic synthesis for the construction of tetrazole derivatives.2 In this study, Fe3O4@SiO2@layered zinc hydroxide (LZH) nanoparticles as an efficient and novel catalysis system were synthesized and applied in Aza-Michael Addition. The catalytic activity of the catalyst was studied for the preparation of the new tetrazoles by the reaction of 5-substituted tetrazoles derivatives with cyclohex-2-eneone under reflux in acetonitrile. Therefore, this catalyst could be recycled and reused at least 5 times without significant loss of its activity.

Keywords:

Layered Zinc hydroxide , Aza-Michael Addition , Tetrazole , Magnetic catalyst