Preparation of MgO/SiO2 nanoparticles as a base catalyst for synthesis of 1H-isochromenes

The 1H-isochromene derivatives have an exceptional structural which appear in numerous natural and non-natural products1. 1H-isochromenes were represented as “advantaged structure” in various medicinally compound such as; their application as antitumor2. Some of these natural compounds are Dendrobium amoenum, Coelogyne Faccida and Faccidin that separated from the orchids3,4.In this study, we prepared the MgO/SiO2 heterogeneous base nanocatalyst in several steps. Then, this nanostructure applied as a nanocatalyst for the synthesis of 1H-isocromenes from cyclohexanones, malononitrile and benzaldehyde in the ethanol solvent under mild conditions. In this reaction, the target products were obtained in excellent yields and short reaction times. At the end of the reaction, the nanocatalyst separated with simple filtration and reused in the other reactions

Keywords:

Nanocatalyst , 1H-Isocromene , Cyclohexanone , Malononitrile , Benzaldehyde