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Differential Expression microRNAs Analysis in Triple Negative Breast Cancer Samples Compared to Non-triple Negative Breast Cancer Samples: In silico analysis of Microarray Data

عنوان مقاله: Differential Expression microRNAs Analysis in Triple Negative Breast Cancer Samples Compared to Non-triple Negative Breast Cancer Samples: In silico analysis of Microarray Data
شناسه ملی مقاله: IBIS09_040
منتشر شده در نهمین همایش بیوانفورماتیک ایران در سال 1398
مشخصات نویسندگان مقاله:

Maryam Khorasani - Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran
Shirin Shahbazi - Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Nazanin Hosseinkhan - Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences,Tehran, Iran
Reza Mahdian - Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran

خلاصه مقاله:
Triple negative breast cancer (TNBC) is one of the breast cancer molecular subtypes that characterized with lack in expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) [1]. As targeted therapy is not available and current treatments for TNBC is not efficient, thus better diagnostic and therapeutic approaches like molecular targets are essential. [2]. MicroRNAs are a group of non-coding RNAs with regulatory effects in biological process [3]. They have potential as candidate diagnostic biomarkers and therapeutic targets in cancers [4]. In this bioinformatics study, we aimed to identify the differential expression microRNAs in TNBC samples compared to non-TNBC samples.

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1164300/