Homa Faraji - Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Farnaz Banakar - Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Azadeh Ebrahim-Habibi - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences

Dead End (Dnd) is an essential RNA binding protein for maintaining viable germ cells in vertebrates. Binding of Dnd to the 3’-UTRs of some mRNAs such as p27 and LATS2 blocks the inhibitory function of microRNAs from these transcripts and in this way helps to maintain p27 and LATS2 protein expression [1]. Human Dnd has two RNA recognition motifs (RRM) including RRM1 and RRM2. p27 has two Dnd interacting sequences (p27-1 and p27-2) [2]. The aim of this study is modeling and simulating of interactions between human Dnd and p27.