Design a Novel Close-Loop Stimulation Framework to Suppress Epileptic Seizures in WAG/Rij Based on ECoG Signal

Original software program is described, which revealed EEG activity characteristic of the onset of epileptic seizure and turned on electrical stimulation of the nucleus basalis of Meynert in WAG/Rij rats with congenital absence epilepsy. The program reliably detected the onset of seizure and automatically stopped it with a high-frequency train of electrical impulses (100-150 Hz). Thus, a feedback system of deep brain stimulation has been developed to stop early manifestations of absence epileptiform seizures. The study can be a base to develop an implanted apparatus to automatically analyze EEG andstimulate the brain to stop the epileptic seizures.

Keywords:

Absence epilepsy , WAG/Rij , brain stimulation , ECoG.