Time-Frequency Analysis of Corticothalamo- Cortical Interaction in Wag/Rij Based on LFP Recording

Generalized spike and wave discharges (SWD) are generated within the cortico-thalamo-cortical system. However, the exact interactions between cortex and different thalamic nuclei are still to be elucidated. In the current experiment, local-field-potential recordings including SWDs were obtained from somatosensory cortex, rostral and caudal RTN, VPM, anterior (ATN) - and posterior (Po) thalamic nucleus in WAG/Rij. WAG/Rij rats were equipped with multiple electrodes targeting layers 4 to 6 of the The maximal associationstrength between signals was calculated for pre-ictal→ictal transition periods and in control periods using time-frequency analysis. Then SWDs were detected from pre-ictal state based on wavelet transform features and MLP neural network. The proposed method detected SDWs with 88 %.

Keywords:

WAG/Rij , SWD , wavelet transform , ECoG , cortex