Saba Fakharianzadeh - Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C., Tehran, IR Iran
Zeinab Shirvani-Farsani - Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C., Tehran, IR Iran

Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that alternate between mania and hypomania or betweendepression and mixed states (1). High rates of misdiagnosis, delayed diagnosis, and lack of recognition and treatment of comorbid conditions oftenlead patients with bipolar illness to have a chronic course with high disability,unemployment rates, and mortality .(2) The molecular mechanism andpathophysiology of bipolar disorder are slightly known. Accordingly, long noncoding RNAs are considered as one of the main factors that aredysfunctional in many diseases such as the nervous system diseases (3). The new comprehensive framework guides the search to identify long-non-codingRNAs to diagnosis, treatment, and training Introduction: Long non-coding RNAs (lncRNAs) are a type of RNA with length greater than 200 nucleotides and play crucial roles in many biological processes and disease including modulation of apoptosis, neuronal development, muscle differentiation, carcinogenesis, and immune responses (8). Long non-coding RNAs (lncRNAs) are regulatory molecules that set many vital processes in the cell. These regulatory RNAs, as an important component of the regulatory networks of genes and the expression of key genes involved in setting development, play an important role in neurological diseases of the central nervous system (CNS)(4) .Methods: Long non-coding RNAs (lncRNAs) are emerging as a critical class of transcripts participating in a wide range of cellular functions. The currentGencode annotation estimates that there are at least 17,952 lncRNA genes (48,438 transcripts) in humans (5). lncRNAs are implicated in controllingtranscription through the inhibition or recruitment of transcription factors, by regulating alternate splicing of the mRNA transcript, by interacting withchromatin to influence the DNA structure and epigenetic state, and by affecting the translation and stability of mRNA via binding to complementarytranscripts or removing miRNA (8). In the present review, we summarize the current literature on function of lncRNAs in bipolar disorder. We investigatedthe PubMed/Medline and google scholar databases.

bipolar disorder, lncRNAs, biomarker, DISC2, MALAT1