Bioinformatics evaluation of targetom hsa-miR-7-1-3p signaling pathways and related function of AR with Prostate Cancer

Prostate tumor growth is almost always dependent upon the androgen receptor pathway and hence therapies aimed at blocking this signaling axis are useful tools in the management of this disease. Unfortunately, such therapies invariably fail; and the tumor progresses to an “androgen-independent” stage. AR expression is increased in Prostate Cancer.Therefor for finding more bioinformatics information we used NCBI, miRbase , miRWALK2.0, Target scan, DAVID database and KEGG pathway hsa-miR-7-1-3p is expected to target the AR gene in the pathway of evading apoptosis. In this study, if bioinformatics predicted that the binding site of microRNA is exactly3/utr of AR gene, and the expected expression of AR and the negative regulatory function of themicroRNAs would be expected. Decreased expression of hsa-miR-7-1-3p is expected to increase the expression of AR and eventually activate the evading apoptosis in people with prostate cancer.

Keywords:

prostate cancer , hsa-miR-7-1-3p , AR