Seyed Mohammad Kazem Aghamir - Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Mahdi Ramezani-binabaj - Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Fatemeh Khatami - Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Behrooz Fatahi - Department of Urology, Lorestan University of Medical Sciences, Lorestan, Iran

IntroductionCurrent hemostatic agents are needed to reduce bleeding and transfusion during several surgery processes. Plant-based absorbable surgical hemostatic agents (microporous polysaccharide hemospheres) are proposed for use in surgical wound sites as an absorbable hemostat and in this study, we checked its efficacy.MethodsThis study was run under the Tehran University of Medical Science Ethics Committee observation based on the clinical trial registry criteria (IRCT20190624043991N1). Total numbers of 42 percutaneous nephrolithotomies (PCNL) patients were enrolled, 21 cases hemostatic powder and 21 controls. Hemostatic powder pumped into Amplatz sheath before its extraction.ResultsThe mean age of the case and control groups was 42.1±19.5, and 42.1±18.5 years, respectively. The median stone size was 11.3±1.85cm. Overall, the differences between sex, age, stone size, and the location were not statistically significant in the two groups (p-value˃0.05). Serum hemoglobin reduction following PCNL was significant in both groups compared to the serum level before surgery (p-value<0.001). However, the difference was not significant between case and control groups postoperatively (p-value=0.727). Yet, postoperative serum creatinine reduction was not significantly different between the two groups compared to preoperative serum levels (p-value>0.05).ConclusionsThe present study showed that microporous polysaccharide hemosphere (MPH) did not affect bleeding reduction, hemoglobin decline, and postoperative blood transfusion, and hospital stay.

Hemostatic Agents, Percutaneous nephrolithotomy, Tubeless Surgeries, microporous polysaccharide hemospheres