Association of BsmI variant of vitamin D receptor gene with polycystic ovary syndrome: A case-control study
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJRM-18-10_007
تاریخ نمایه سازی: 17 فروردین 1400
Abstract:
Background: Polycystic ovarian syndrome (PCOS) is an endocrine disorder that affects womenchr('39')s fertility and causes alterations such as obesity, insulin resistance, menstrual irregularities, and polycystic ovaries. The results of the studies show that the issue of vitamin D and vitamin D receptor (VDR) is controversial for PCOS susceptibility.
Objective: To investigate the association of BsmI polymorphism in the VDR gene with metabolic parameters in obese PCOS women.
Materials and Methods: In this case-control study, 38 obese subjects with PCOS and 40 unrelated obese individuals were evaluated to determine the allelic and genotypic frequency of BsmI variant by Polymerase Chain Reaction Restriction Fragment Length Polymorphism method. Body Mass Index, parathyroid hormone, phosphorus, and calcium were evaluated in all participants.
Results: BsmI (rs1544410), (A/G) AA, AG, GG, A, and G percentage of genotypic/allelic frequencies were 65.8, 26.3, 7.9, 78.9, and 21.1 in cases and 57.5, 40, 2.5, 77.5, and 22.5 in controls, respectively. Statistical analysis revealed that the differences in genotypic (p = 0.31)/allelic (p = 0.83) frequencies and dominant (p = 0.45)/recessive (p = 0.35) models between the cases and controls were not significant. This study indicates no association between the BsmI genotypes and metabolic parameters.
Conclusion: It can be concluded that VDR BsmI (rs1544410) Intron 8 (A>G) was not associated with obesity along with PCOS susceptibility in the studied groups.
Keywords:
Vitamin D receptor , Polycystic ovary syndrome , Genetic association study. , گیرنده ویتامین D , سندرم تخمدان پلی کیستیک , ارتباط ژنتیکی.
Authors
Nasim Ramazani
Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Maryam Ostadsharif
Department of Medical Basic Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. Department of Medical Biotechnology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Hashem Nayeri
Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
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