The role of caspase-dependent and caspase-independent pathways of apoptosis in the premature rupture of the membranes: A case-control study

Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJRM-18-6_005

تاریخ نمایه سازی: 17 فروردین 1400

Abstract:

Background: Premature rupture of membrane (PROM) remains a problem in obstetrics, the mechanisms of PROM have not been clearly defined. Apoptosis is thought to play a key role in the mechanism, via caspase-dependent and caspase-independent pathways. Caspase-3, Apoptosis-inducing factor (AIF), and anti-apoptosis B-cell lymphoma 2 (Bcl-2) are hypothesized to be involved in PROM. Objective: To determine the role of caspase-dependent and caspase-independent pathways in the mechanism of PROM. Materials and Methods: This was a case-control study involving 42 pregnant women with gestational age between 20-42 wk. Participants were divided into the case group (with PROM) and control group (without PROM). Amniotic membranes were collected immediately after the delivery, and samples were taken from the site of membrane rupture. Immunohistochemical examination was done to determine the expression of Caspase-3, AIF, and Bcl-2. Results: The expressions of Caspase-3 (OR = 9.75; 95% CI = 2.16-43.95; p = 0.001) and AIF (OR = 6.60; 95% CI = 1.48-29.36; p = 0.009) were significantly increased, whereas, Bcl-2 expressions (OR = 8.00; 95% CI = 1.79-35.74; p = 0.004) were significantly decreased in the case group. Conclusion: High Caspase-3, AIF, and low Bcl-2 expression were the risk factors for PROM. Thus, it is evident that caspase-dependent and caspase-independent pathways are involved in the mechanism of PROM.

Authors

Ketut Surya Negara

Department of Obstetrics and Gynecology, Medical Faculty of Udayana University, Sanglah Hospital, Bali, Indonesia.

Ketut Suwiyoga

Department of Obstetrics and Gynecology, Medical Faculty of Udayana University, Sanglah Hospital, Bali, Indonesia.

Raka Sudewi

Department of Neurology, Medical Faculty of Udayana University, Sanglah Hospital Bali, Indonesia.

Nyoman Mantik Astawa

Laboratory of Veterinary Medicine, Udayana University Bali, Indonesia.

Gusti Nyoman Kamasan Arijana

Biomedic Laboratory of Medical Faculty Udayana University, Bali, Indonesia.

Ketut Tunas

Department of Public Health, Dhyana Pura University Bali, Indonesia.

Tjokorda Gede Astawa Pemayun

Department of Obstetrics and Gynecology, Medical Faculty of Udayana University, Sanglah Hospital, Bali, Indonesia.

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  • Adeniji AO, Atanda OA. Interventions and neonatal outcomes in patients ...
  • Endale T, Fentahun N, Gemada D, Hussen MA. Maternal and ...
  • Budijaya M, Surya Negara IK. Labor profile with premature rupture ...
  • Mercer BM. Preterm premature rupture of the membranes. Obstet Gynecol ...
  • https://doi.org/10.1097/00006250-200301000-00033 ...
  • Rodrigo MRR, Kannamani A. Perinatal and maternal outcome in premature ...
  • Thombre MK. A review of the etiology epidemiology prediction and ...
  • Benirschke, K. Anatomy and Pathology of the Placental Membranes. In: ...
  • Vishwakarma K, Patel SK, Yadav K, Pandey A. Impact of ...
  • Tency I, Verstraelen H, Kroes I, Holtappels G, Verhasselt B, ...
  • Garite TJ. Premature rupture of the membrane. In: Creasy RK, ...
  • Rangaswamy N, Kumar D, Moore RM, Mercer BM, Mansour JM, ...
  • Sukhikh GT, Kan NE, Tyutyunnik VL, Sannikova MV, Dubova EA, ...
  • Xu J, Wang HL. Role of caspase and MMPs in ...
  • Elmore S. Apoptosis: a review of programmed cell death. Toxicol ...
  • Hongmei Z. Extrinsic and intrinsic apoptosis signal pathway review. Available ...
  • Estaquier J, Vallette F, Vayssiere JL, Mignotte B. The mitochondrial ...
  • Van Loo G, Schotte P, Van Gurp M, Demol H, ...
  • Ashkenazi A, Salvesen G. Regulated cell death: signaling and mechanisms. ...
  • Galluzzi L, Kepp O, Trojel-Hansen C, Kroemer G. Mitochondrial control ...
  • Menon R, Fortunato SJ. The role of matrix degrading enzymes ...
  • Perfettini JL, Hospital V, Stahl L, Jungas T, Verbeke P, ...
  • Harirah HM, Borahay MA, Zaman W, Ahmed MS, Hankins GD. ...
  • Parsons MJ, Green DR. Mitochondria in cell death. Essays Biochem ...
  • Vaux DL. Apoptogenic factors released from mitochondria. Biochim Biophys Acta ...
  • Saglam A, Ozgur C, Derwig I, Unlu BS, Gode F, ...
  • Kataoka S, Furuta I, Yamada H, Kato EH, Ebina Y, ...
  • El Khwad M, Stetzer B, Moore RM, Kumar D, Mercer ...
  • Reti NG, Lappas M, Riley C, Wlodek ME, Permezel M, ...
  • Candé C, Cohen I, Daugas E, Ravagnan L, Larochette N, ...
  • Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, ...
  • Akematsu T, Endoh H. Role of apoptosis-inducing factor (AIF) in ...
  • Negara KS, Suwiyoga K, Arijana K, Tunas K. Role of ...
  • Negara KS, Suwiyoga K, Arijana K, Tunas K. Role of ...
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