Serum Levels of Soluble Fas and Fas Ligand in Iranian Women with Pre-eclampsia

Background: The precise responsible mechanism of pre-eclampsia remains controversial however, recent data suggest a main role of the abnormal activation of the adaptive immune system and Apoptosis. In this study, we have measured serum levels of Fas/Fasl as two important members of extrinsic apoptotic pathway in patient with pre-eclampsia. Methods: ۲۰۷ participants including ۹۹ pre-eclampsia patients and ۱۰۸ age and sex-matched normal pregnant women were involved in the case-control study. Plasma sample from each participant was collected and stored at –۲۰ ̊C until batch processing. Serum levels of Fas and Fas ligand were measured by ELISA for each participant including ۹۹ pre-eclampsia patients and ۱۰۸ normal pregnant women. Following a test of statistical normality, nonparametric data were analyzed by Mann-Whitney. Results: sFas levels in case group was significantly higher than controls; ۵۸۴ (۳۹۷-۸۹۲) pg/ml in cases opposed to ۳۴۱ (۲۱۳-۶۰۲) pg/ml in controls (p value< ۰.۰۱). sFasL in pre-eclampsia women was a little lower than controls; ۲۵۵ (۱۷۳-۳۱۸) pg/ml and in case group compared to ۲۶۵.۵ (۱۸۴-۳۸۱.۵) pg/ml in controls. Conclusions: We have found the increased levels of sFas in patients with pre-eclampsia in compare with the healthy pregnant women. It seems that abnormality in sFAS is related with pre-eclampsia.

Keywords:

Pre-eclampsia , Pregnancy , sFAS , sFASL , Apoptosis.