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Title

Diagnostic performance of 18F-FDG PET-CT in patients presenting with secondary neck nodes from an unknown primary

Year: 1400
COI: JR_IRJNM-29-1_003
Language: EnglishView: 30
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Authors

Manjit Sarma - Department of Nuclear Medicine and Molecular
Subramanyam Padma - Department of Nuclear Medicine and Molecular
Palaniswamy Shanmuga Sundaram - Department of Nuclear Medicine and Molecular

Abstract:

Introduction: Clinical examination and even anatomical imaging may fail to identify primary site of malignancy in patients presenting with cervical nodal metastasis. 18F-Fluorodeoxyglucose Positron Emission Computed Tomography (18F-FDG PET-CT) is known to overcome the limitations of anatomic imaging. Methods: Sixty-three (63) patients (male:female=55:8, age range=32-83 years, mean age=61.14 ±12.6 years) with one or more metastatic neck node (s) from occult primary underwent 18F-FDG PET-CT. Nodal cytological/biopsy findings, IHC of cervical nodal biopsy (whenever available), scan findings, subsequent biopsy findings (PET guided/ directed)  of suggested occult primaries were correlated. Subsequent detection of any primary malignancy in whom 18F-FDG PET-CT failed to localize a primary was also documented. Results: Malignancy was confirmed in eighteen (18) out of those twenty-four (24) patients in whom site of possible occult primary malignancy was suggested out of total sixty-three (63) patients. In five (5) patients out of remaining thirty-nine (39) patients, a site of primary malignancy was detected or a site of primary malignancy was considered based on IHC subsequently. The detection rate of occult primary, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and false positivity rate was calculated to be 28.5%, 78.2%, 85%, 75%, 87.1% and 15% respectively. 18F-FDG PET-CT also detected other lymph nodal and organ metastases in 46% and 23.8% patients respectively. Conclusion: 18F-FDG PET-CT is a useful modality for detecting unknown primary and other nodal /distant metastases in patients presenting with neck nodal metastases.

Keywords:

Metastatic neck nodes , Carcinoma of unknown primary , 18F-FDG PET-CT

Paper COI Code

This Paper COI Code is JR_IRJNM-29-1_003. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1180852/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Sarma, Manjit and Padma, Subramanyam and Sundaram, Palaniswamy Shanmuga,1400,Diagnostic performance of 18F-FDG PET-CT in patients presenting with secondary neck nodes from an unknown primary,https://civilica.com/doc/1180852

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    COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

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