The effect of propofol, ketamine and ketofol on intraocular pressure after intravenous premedication with xylazine in Iranian male rabbits

The current study was performed to determine the comparative effects of intravenous administration ofpropofol, ketamine and ketofol on intraocular pressure after intravenous premedication with xylazine (0.8mg/kg) in Iranian male rabbits. Twenty healthy Iranian male white rabbits were randomly received each oneof three anaesthetic regimens separately at 14 day intervals. The intraocular pressure was measured atbaseline, 25 minutes after xylazine administration, and at 3,5,15, 20 and 25 minutes following induction. Themean of the left and right intraocular pressure was assumed as the Rabbits intraocular pressure. Data reveledfrom current study showed that the induction of anesthesia was occurred without using additional injectionsin all groups and there were no complication was observed during anesthesia and the recovery process wassmooth and uneventful in all experimental rabbits. The mean intraocular pressure was highest in ketaminegroup and lowest in ketofol group at 25 minutes after the induction. Ketamine administration followingpremedication with xylazine decreased the intraocular pressure. Intravenous ketamine and propofolcombination in Iranian white rabbits was reduced the intraocular pressure compared to propofol andketamine, alone and Ketofol also may be an agent of choice for ophthalmic procedures.

Keywords:

Intravenous administration , Propofol , Ketamine , Ketofol , Intraocular pressure , Xylazine , Rabbits