Ameliorative Effect of Melatonin Versus the Passage of Time and Lipid Peroxidation on Sperm Motility in Asthenotratospermic Men
Publish place: Jorjani Biomedicine Journal، Vol: 9، Issue: 1
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JOBJ-9-1_007
تاریخ نمایه سازی: 6 اردیبهشت 1400
Abstract:
Background and Objective: Downscale outcome in assisted reproductive techniques (ART) is associated with lipid peroxidation. Melatonin may have beneficial effects against lipid peroxidation and oxidative stress. This work was aimed to evaluate the ameliorative capacity of melatonin versus the passage of time and lipid peroxidation on sperm parameters from the men with ATS in the ART process.
Material and Methods: Semen samples were collected from ۵۰ asthenoteratozoospermic (ATS) men. Samples were divided into control and melatonin group. The test group were incubated with ۶ mM melatonin at ۲, ۴, ۶, and ۲۴ hours. Then total and progressive motility, membrane integrity, and Malondialdehyde levels (MDA) were evaluated. Statistical analysis was carried out by SPSS software (repeated-measures ANOVA).
Results: In the control group, total (p<۰.۰۱) and progressive (P<۰.۰۵) motility and also, membrane integrity (P<۰.۰۳) significantly decreased although, MDA levels of sperm significantly increased (*P<۰.۰۴). Moreover, in the melatonin group, the mentioned parameters significantly compensated compared to the control group (P<۰.۰۵).
Conclusion: In the outcome, melatonin in vitro treatment paves the way for motility and membrane integrity up-regulating in the ATS men.
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Authors
Ghadir Sohrabi
Tabriz University of Medical Sciences International Branch Aras
Mahdi Malmir
Department of Midwifery, Tuyserkan Branch, Islamic Azad University, Tuyserkan, Iran
Ali Asghar Ghafarizade
Academic Center for Education, Culture and Research, Arak, Iran
Tayebeh Faraji
Academic Center for Education, Culture and Research, Arak, Iran
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