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Title

Retinoic acid –loaded core-shell fibrous scaffold for neuronal differentiation of trabecular mesenchymal stem cells

مجله علوم نانو، دوره: 8، شماره: 1
Year: 1400
COI: JR_NAMJ-8-1_008
Language: EnglishView: 87
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Authors

Khatereh Asadi - Department of Medical Nanotechnology, Zanjan University of Medical Sciences, Zanjan, Iran
Yousef Mortazavi - Department of Medical Biotechnology, Zanjan University of Medical Sciences, Zanjan, Iran
Samad Nadri - Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Abstract:

Objective(s): Scientists believe that they can fabricate a biochemical scaffold and seed stem cells on it to create an extracellular matrix for tissue generation. This study sought to develop retinoic acid (RA)-loaded core-shell fibrous scaffolds (Poly-Caprolactone (PCL)/Polyethylene Oxide (PEO) based on electrospinning technique, to examine neural differentiation of trabecular mesenchymal stem cells (TM-MSCs). Materials and Methods: PEO-PCL core- shell fibrous scaffold was fabricated using coaxial electrospinning and Fourier transform infrared (FTIR) used to evaluate the chemical bond structure, scanning electron microscopy (SEM) has been utilized to evaluate surface topography and fibrous diameter, and transient electron microscopy (TEM) to evaluate core-shell structure. The neural differentiation was evaluated using Real-Time PCR.Results: The results of FTIR, SEM, and TEM confirm the fabrication of core-shell fibrous of PEO-PCL. The fabricated scaffold provides a suitable substrate for adhesion, cell proliferation, and differentiation. SEM images show changes in the morphology of TM-MSCs to neuronal cells. A sustained release of RA from the PEO/PCL scaffold was detected over ۱۴ days. In addition, quantifying the expression of the gene indicates an increase in the gene expression of microtubule-associated protein ۲ (MAP-۲) gene.Conclusion:The PEO/PCL core-shell fibrous scaffold containing a RA constructed using coaxial electrospinning technique was a suitable substrate for inducing neuronal differentiation of TM-MSCs cultivated on core-shell scaffold.

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Paper COI Code

This Paper COI Code is JR_NAMJ-8-1_008. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1186849/

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Asadi, Khatereh and Mortazavi, Yousef and Nadri, Samad,1400,Retinoic acid –loaded core-shell fibrous scaffold for neuronal differentiation of trabecular mesenchymal stem cells,https://civilica.com/doc/1186849

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The specifications of the publisher center of this Paper are as follows:
Type of center: علوم پزشکی
Paper count: 1,084
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