Evaluation of the Effects of Letrozole in Combination with Neoadjuvant Chemotherapy on Clinical Response Rate of Breast Cancer
Publish place: Journal of Cardio-Thoracic Medicine، Vol: 9، Issue: 1
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_JCTM-9-1_005
تاریخ نمایه سازی: 6 اردیبهشت 1400
Abstract:
AbstractThis randomized clinical trial was aimed to assess the efficacy of neoadjuvant letrozole in combination with standard neoadjuvant chemotherapy regimen on clinical response rate of hormone receptor positive locally advanced breast cancer.In this randomized clinical study, ۴۲ female patients, ≥ ۱۸ years, with clinical stage IIB-IIIC (T۱-۴, N۰-۳, M۰), pathologically proven hormone receptor positive and HER۲ negative, invasive ductal carcinoma of breast, were randomly assigned to receive standard neoadjuvant chemotherapy alone (control group) or letrozole ۲.۵ mg/d (in association with goserlin in premenopausal patients) concurrent with standard neoadjuvant chemotherapy (study group). Standard neoadjuvant chemotherapy regimen has consisted of ۴ cycles of doxorubicin (۶۰mg/m۲) and cyclophodphamide (۶۰۰mg/m۲), followed by ۴ cycles of paclitaxel (۱۷۵mg/m۲) every two weeks.At the beginning of the study all patients underwent thorough exmination of breast mass and axillary lymph nudes by palpation and ultrasonography. At the end of the study response rates were also evaluated by palpation and ultrasonography and subsequently patients were referred for surgury. Pathologic response rates were also evaluated on surgical specimens. All of the clinical, ultrasonographic and pathologic examinations during the trial were performed by a single specialist. Finally all the data were analysed statistically.Overall clinical response rates in breast were ۹۵.۲%, in both study and control group. Overall clinical response rates in axilla were ۸۰.۹% and ۷۶.۲% in study and control group respectively. Similarly, overall radiologic complete response rates in breast and axilla were ۹۵.۲% and ۷۶.۲% respectively in both study and control group. Totally, the comparison of overall clinical and radiologic response rates in th breast and axilla, showed no significant difference between control and study group (p>۰.۰۵).The addition of letrozol to standard neoadjuvant chemotherapy regimen was not associated with higher clinical and radiologic response rates in patients with locally advanced hormon receptor positive breast cancer.Keywords: Neoadjuvant chemotherapy, Letrozole, Locally advanced breast cancer
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Authors
Zahra Mozahheb
Department of Medical Oncology and Hematology, Imam Reza Hospital, Mashhad, Iran.
Abolghasem Alahyari
Department of Medical Oncology and Hematology, Imam Reza Hospital, Mashhad, Iran.
Seyyedeh Fatemeh Seyyedi Khabbaz
Department of Medical Oncology and Hematology, Imam Reza Hospital, Mashhad, Iran
Asieh Sadat Fattahi
Minimally Invasive and Endoscopic Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mona Najaf Najafi
Department of Statistics and Social Medicine, Imam Reza Hospital, Mashhad, Iran.
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