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Evaluation of the Effects of Letrozole in Combination with Neoadjuvant Chemotherapy on Clinical Response Rate of Breast Cancer

مجله پزشکی قلب و قفسه سینه، دوره: 9، شماره: 1
Year: 1400
COI: JR_JCTM-9-1_005
Language: EnglishView: 116
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Zahra Mozahheb - Department of Medical Oncology and Hematology, Imam Reza Hospital, Mashhad, Iran.
Abolghasem Alahyari - Department of Medical Oncology and Hematology, Imam Reza Hospital, Mashhad, Iran.
Seyyedeh Fatemeh Seyyedi Khabbaz - Department of Medical Oncology and Hematology, Imam Reza Hospital, Mashhad, Iran
Asieh Sadat Fattahi - Minimally Invasive and Endoscopic Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mona Najaf Najafi - Department of Statistics and Social Medicine, Imam Reza Hospital, Mashhad, Iran.


AbstractThis randomized clinical trial was aimed to assess the efficacy of neoadjuvant letrozole in combination with standard neoadjuvant chemotherapy regimen on clinical response rate of hormone receptor positive locally advanced breast cancer.In this randomized clinical study, ۴۲ female patients, ≥ ۱۸ years, with clinical stage IIB-IIIC (T۱-۴, N۰-۳, M۰), pathologically proven hormone receptor positive and HER۲ negative, invasive ductal carcinoma of breast, were randomly assigned to receive standard neoadjuvant chemotherapy alone (control group) or letrozole ۲.۵ mg/d (in association with goserlin in premenopausal patients) concurrent with standard neoadjuvant chemotherapy (study group). Standard neoadjuvant chemotherapy regimen has consisted of ۴ cycles of doxorubicin (۶۰mg/m۲) and cyclophodphamide (۶۰۰mg/m۲), followed by ۴ cycles of paclitaxel (۱۷۵mg/m۲) every two weeks.At the beginning of the study all patients underwent thorough exmination of breast mass and axillary lymph nudes by palpation and ultrasonography. At the end of the study response rates were also evaluated by palpation and ultrasonography and subsequently patients were referred for surgury. Pathologic response rates were also evaluated on surgical specimens. All of the clinical, ultrasonographic and pathologic examinations during the trial were performed by a single specialist. Finally all the data were analysed statistically.Overall clinical response rates in breast were ۹۵.۲%, in both study and control group. Overall clinical response rates in axilla were ۸۰.۹% and ۷۶.۲% in study and control group respectively. Similarly, overall radiologic complete response rates in breast and axilla were ۹۵.۲% and ۷۶.۲% respectively in both study and control group. Totally, the comparison of overall clinical and radiologic response rates in th breast and axilla, showed no significant difference between control and study group (p>۰.۰۵).The addition of letrozol to standard neoadjuvant chemotherapy regimen was not associated with higher clinical and radiologic response rates in patients with locally advanced hormon receptor positive breast cancer.Keywords: Neoadjuvant chemotherapy, Letrozole, Locally advanced breast cancer


Neoadjuvant chemotherapy , Letrozole , locally advanced breast cancer

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Mozahheb, Zahra and Alahyari, Abolghasem and Seyyedi Khabbaz, Seyyedeh Fatemeh and Fattahi, Asieh Sadat and Najaf Najafi, Mona,1400,Evaluation of the Effects of Letrozole in Combination with Neoadjuvant Chemotherapy on Clinical Response Rate of Breast Cancer,

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