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Title

Non-collagenous extracellular matrix protein dermatopontin may play a role as another component of transforming growth factor-β signaling pathway in colon carcinogenesis

مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 4
Year: 1400
COI: JR_IJBMS-24-4_004
Language: EnglishView: 147
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Authors

Ariane Sadr-Nabavi - Medical Genetic Research Center (MGRC), School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Samaneh Bouromand-Noughabi - Department of Pathology, Faculty of Medicine, Mashhad, University of Medical Sciences, Mashhad, Iran
Naser Tayebi-Meybodi - Department of Pathology, Faculty of Medicine, Mashhad, University of Medical Sciences, Mashhad, Iran
Kimia Dadkhah - Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Nafiseh Amini - Medical Genetic Research Center (MGRC), School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Alfons Meindl - Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, München, Germany
Mohammad Reza Abbaszadegan - Medical Genetic Research Center (MGRC), School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

Objective(s): Dermatopontin (DPT) is an extracellular matrix protein that plays roles in increasing the activity of transforming growth factor-β (TGF-β) and induction of cell quiescence. These roles suggest a tumor suppressor function for DPT. This study aimed to investigate changes in DPT gene expression in colorectal cancer providing a better understanding of its carcinogenesis.Materials and Methods: We used Matched Tumor/Normal Expression Array and Cancer Profiling Arrays I containing ۳۴ and ۷ cases of colorectal cancer and their matched controls, respectively, to test DPT expression. In addition, ۳۸ newly diagnosed cases of colorectal cancer were enrolled and their fresh colonic tumoral and normal specimens were obtained. DPT mRNA expression was analyzed using real-time PCR. In cases with DPT under expression, exonic regions of the DPT gene were sequenced using the Sanger method.Results: In array samples, DPT expression was decreased in ۸۲.۹% (۳۴/۴۱), increased in ۱۲.۲% (۵/۴۱), and had no changes in ۴.۹% (۲/۴۱). DPT was decreased in ۱۴ fresh samples (۳۶.۸%), while ۱۲ cases (۳۱.۶%) showed overexpression and the others had no changes. DPT expression showed no significant difference among various tumor grades and stages. The frequencies of DPT overexpression were higher in tumors having lymph node involvement (۴۷.۷% vs ۲۸%, P=۰.۵۹). In ۲ cases mutations were detected that may be responsible for decreased expression of DPT.Conclusion: The similarities between changing patterns of DPT and TGF-β expression in colorectal cancer demonstrate that DPT may act as a pre-receptor component of the TGF-β signaling pathway in colon carcinogenesis.

Keywords:

Colorectal cancer Dermatopontin Real , Time PCR Sanger sequencing TGF , β

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This Paper COI Code is JR_IJBMS-24-4_004. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1186913/

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Sadr-Nabavi, Ariane and Bouromand-Noughabi, Samaneh and Tayebi-Meybodi, Naser and Dadkhah, Kimia and Amini, Nafiseh and Meindl, Alfons and Abbaszadegan, Mohammad Reza,1400,Non-collagenous extracellular matrix protein dermatopontin may play a role as another component of transforming growth factor-β signaling pathway in colon carcinogenesis,https://civilica.com/doc/1186913

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Type of center: علوم پزشکی
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