Heng Tang - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China
Qingfu Zeng - Department of vascular surgery, The Second Affiliated Hospital of Nanchang University
Nina Ren - Guangdong Online Hospital Clinic, Guangdong Second Provincial People’s Hospital, Guangzhou ۵۱۰۳۱۷, PR China
Yunjie Wei - Taihe Hospital Shiyan, Hubei, PR China
Quan He - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China
Ming Chen - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China
Peng Pu - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China

Objective(s): Kaempferide (Ka), a major natural active component of Tagetes erecta L, has numerous pharmacological effects such as anti-obesity, anticancer, and anti-hypertension. However, there is no clear evidence that Ka is directly related to inflammation and oxidative stress in obese mice. We aimed to explore the effects of Ka on inflammation and oxidative stress and its mechanism.Materials and Methods: The obese mice were induced by a high-fat diet (HFD). The anti-obesity effect was tested by liver and body weight, liver and adiposity index, and white adipose tissue. Blood sample analysis was used to detect the hypolipidemic and hypoglycemic effects. The anti-oxidation effect was assessed using GSH, SOD, MDA, CAT, T-AOC, and other indicators. The anti-inflammatory effect was assessed using TNF-α, MCP-۱, and Adiponectin. Western blot and Real-Time PCR were used to evaluate the related signaling pathways.Results: Obesity, glycolipid metabolism disorder, inflammation, and oxidative stress developed in HFD mice. These changes can be effectively alleviated by Ka treatment for ۱۶ weeks. Further studies have suggested that these beneficial effects of Ka may be associated with inhibition of the TLR۴/IκBα/NF-κB signaling pathways. Conclusion: Ka possesses important anti-obesity, hypoglycemic, and hypolipidemic effects. The mechanism may be causally associated with the TLR۴/IκBα/NF-κB signaling pathway, which improves inflammation and oxidative stress.

Anti, inflammatory Anti, oxidation Kaempferide Obesity TLR۴