Comparative evaluation of conscious sedation effect of Propofol versus Midazolam in endoscopic and colonoscopic procedures
Publish Year: 1381
نوع سند: مقاله ژورنالی
زبان: English
View: 199
This Paper With 5 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ZUMS-10-40_005
تاریخ نمایه سازی: 11 اردیبهشت 1400
Abstract:
Background: Endoscopic procedures are performed for diagnosis and treatment of GI disturbances and require adequate, short-time anesthesia. Propofol is a rather recently introduced IV drug used for its conscious sedation effects. This study has compared the effects and complications of propofol versus midazolam in endoscopic procedures in Hamedan in ۲۰۰۱. Materials and Methods: This double blind randomized clinical trial was performed on ۷۰ patients at ASA class I- II who underwent endoscopy or colonoscopy at Ekbatan Hospital in Hamedan. After randomization of the patients into ۲ study groups: test (propofol) and control (midazolam), phentanil (۵mg/kg) was administered as a sedative and after ۳ minutes contents of syringe A (propofol) or B (midazolam) were injected by an anesthesiologist. Then, the ۲ groups were compared regarding such points as injection pain, conscious sedation, operation satisfaction (by the patient), duration of recovery, nausea and vomiting, hypotension and decrease in O۲ saturation. Results: Average score of conscious sedation in midazolam group (۴.۱) was slightly higher than propofol group (۴). Mean duration of recovery was ۱۵.۳ in midazolam and ۱۴.۸ in propofol groups. A total of ۱۴ patients (۴۰%) in midazolam group and ۷ patients (۲۰%) in propofol group experienced complications whose difference was not statistically significant. Mean pain score in midazolam group (۲.۷) was slightly higher than propofol group (۲.۶). Mean satisfaction score was also slightly higher in midazolam group (۳.۲۳) vs propofol group (۳.۲). Conclusion: There was no statistically significant difference between propofol and midazolam from the point of view of conscious sedation, patient satisfaction, duration of recovery, injection pain and other complications.
Keywords: