The effect of preipheral injection of hydrocortisone on withdrawal syndrome sign in addict mice

Background: Tolerance and dependency are two main problems that have limited morphine administration. There are several reports concerning the role of some of these factors in the occurrence of tolerance and dependency. It has been suggested that corticosteroids drug may be involved in morphine-induced tolerance and dependency. Aim of this study were investigated the effect of hydrocortisone (۵, ۱۰ mg/kg SC) on withdrawal syndrome sign. Material and Methods: Male albino mice (۲۵-۳۰ gr) were used in this study. The animals divided into three groups, one control (Vehicle) and two test (drug) groups. Morphine was used to produce drug dependency by Marshall Method. The number Jumping and amount of weight loss was used for measuring intensity of morphine dependency and classic withdrawal syndrome sign.. Results: The data indicated that hydrocortisone in both doses significantly decrease withdrawal syndrome signs (P<۰.۰۱). Conclusion: Finding above indicated that steroid receptor is important in withdrawal syndrome signs in morphine dependent animals. This effect induced probably via activation of neurotransmitter systems in different brain regions.

Keywords:

Hydrocortisone , Morphine , Withdrawal syndrome , Mice