Effect of Alcoholic Extract of Dorema auchrei on Homogram in Adult Male Rats

Background and Objectives: Dorema aucheri belonging to the umbrella family plants, is used as food by the local residents of the Southern Iran. It is believed that this plant contains medication properties. In this research, the effect of different qnuantities of Dorema aucheri extract on homogram in adult male rats were investigated. Materials and Methods: Forty adult male rats from wistar inbred were randomly divided into the following groups: control, sham operated and experimental groups. Experimental groups subdivided into three groups and received different doses of the plant alcoholic extract, ۱۰۰, ۲۰۰ and ۴۰۰ mg/kg for ۳۰ days. The sham group recieved normal saline and the control group received nothing. At the end of ۳۰th day, blood was taken from ventricle of the heart of the rats from all groups followed by routine hematology tests. The whole numbers of white blood cells (WBC), red blood cells (RBC), hematocrit, MCV, MCH, MCHC, lymphocyte percentage and monocytes and platelets were measured and the results were analysed. Results: The results showed that using Dorema aucheri alcoholic extract at the end of ۳۰th day, caused a significant increase in monocytes number in the experiment group comparing to the control group. The rate of platelet at the end of ۳۰th day showed a significant decrease in the test group. Conclusion: The results indicated that Dorema aucheri probably contains flovonoidic component with antioxidant effect leading to the increase of monocytes and with inhibitory effect on thromboxane A۲ production, causing a dicrease in platelet production.

Keywords:

Dorema aucheri , Homogram , Adult Male Rat