Study of the Effects of Hexamethylenetetramine (HMT) on the Number of Pleural Visceral Layer Mast Cells in Rats after Exposure to Sulfur Mustard (HD).

Publish Year: 1387
نوع سند: مقاله ژورنالی
زبان: English
View: 179

This Paper With 10 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_ZUMS-16-65_004

تاریخ نمایه سازی: 11 اردیبهشت 1400

Abstract:

Background and Objective: Sulfur mustard is a potent chemical vesicant warfare agent that remains a significant military and civilian threat. Inhalation of sulfur mustard gas causes inflammation and injury to airways and bronchioles. Mast cells promote allergic reactions when exposed to some chemical compounds such as HD. Hexamethylenetetramine has been shown to protect human lung cells against HD toxicity and has also been shown to be effective against the chemical warfare agent phosgene in vivo. The aim of this study was to evaluate the effects of HMT on the number of mast cells in the lamina propria of visceral layer of pleura in male rats after exposure to sulfur mustard. Materials and Methods: Twenty seven Albino Wister male rats weighting ۲۰۰±۲۰ gr were randomly divided into ۵ groups (Normal Saline (N.S), HMT, HD, Pre-exposure and Post-exposure). HD, Pre-exposure and Post-exposure groups received sulfur-mustard and N.S group received Normal Saline as a solvent by intratracheal catheter. HMT, Pre-exp and Post-exp groups received HMT via intra-peritoneal for ۱۴ days. After the day ۱۴, body weight changes, the rate of lung tissue injury and the number of mast cells measured in the pleurachr('۳۹')s visceral layer of the ratschr('۳۹') lungs. Results: Histological examination and mast cells count showed no significant difference when compared among NS, HMT, Pre-exposure and Post-exposure groups. However, significant reduction was seen in the number of mast cells in HMT and NS groups in comparison with the HD group (p < ۰/۰۰۱). The number of mast cells in the Pre-exposure and Post-exposure groups was also significantly lower than that of the HD group (p < ۰/۰۰۱). Conclusions: From the results of this study it can be concluded that HMT may have a positive protective and therapeutic effect on lung tissue in rats. Key words: Sulfur mustard, Lung, Mast cell, Hexamethylenetetramine, Rat

Keywords:

Key words: Sulfur mustard , Lung , Mast cell , Hexamethylenetetramine , Rat

Authors

زهرا عبدی

Emam Hosien Hospital, Zanjan, Iran

سید همایون صدرایی

Dept. of Anatomy, Baghiyatallah University of Medical Sciences, Tehran, Iran

غلامرضا کاکا

Dept. of Anatomy, Baghiyatallah University of Medical Sciences, Tehran, Iran

مهوش جعفری

Dept. of Biochemistery, Faculty of Medicine, Baghiyatallah University of Medical sciences, Tehran, Iran

مهدی صابری

Dept. of pharmacology, Faculty of Medicine, Baghiyatallah University of Medical sciences, Tehran, Iran

محمد حسن حسینی اکبری

Baghiyatallah Hospital, Baghiyatallah University of Medical Sciences, Tehran, Iran

حسین دشت نورد

Dept. of Anatomy, Baghiyatallah University of Medical Sciences, Tehran, Iran

علی پندوه

Dept. of Immunology, Baghiyatallah University of Medical Sciences, Tehran, Iran