Comparison of Intravenous Oxytocin and Oral Misoprostol in Reduction of Postpartum Hemorrhage

Background and Objective: Postpartum hemorrhage ranks among the most leading causes of maternal morbidity and mortality in the world. Intravenous oxytocin is routinely used to reduce postpartum hemorrhage. The aim of this study was to compare the effect of ۴۰۰ µg of oral misoprostol versus ۱۰ IU of intravenous oxytocin in preventing postpartum hemorrhage. Materials and Methods: This randomized clinical trial, which was conducted at the Kosar Hospital in Qazvin, included ۲۶۹ pregnant women. Inclusion criteria were: singleton pregnancy, over ۳۷ weeks of gestation parity of less than ۳ vertex presentation spontaneous or induced labor and an estimated fetal weight under ۴ kg. Exclusion criteria included: history of postpartum hemorrhage asthma coagulopathy and anticoagulant consumption presence of placental abruption postpartum hemorrhage due to lacerations instrumental delivery and cesarean section. Selected patients randomly received either ۴۰۰ µg of oral misoprostol or ۱۰ IU of intravenous oxytocin after delivery of the anterior shoulder or within the first minute after the delivery. Hemoglobin and hematocrit were measured both during admission and ۲۴ hours after the delivery and were compared together. Results: Postpartum hematocrit drop occurred in ۳.۳۳% +۳.۴۴ of the participants in the oxytocin group compared with ۲.۸۱% +۱.۲۶ in the misoprostol group. The rate of using additional oxytocin was ۳۴.۸% in the oxytocin group versus ۲۰.۵% in the misoprostol group. Fever occurred in ۲ of the women in the misoprostol group. Conclusion: Administration of ۴۰۰ µg oral misoprostol appears to be as effective as ۱۰ IU of intravenous oxytocin in reducing the blood loss after delivery.

Keywords:

Keywords: Postpartum hemorrhage , Misoprostol , Oxytocin