مهشید تهمتن - Physiology-pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
محمدالله توکلی - Physiology-pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
محمد محسن تقوی - Dept. of Anatomy, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
حسین رضازاده - Physiology-pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
محمد کاظمی عرب آبادی - Infectious and Tropical Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
علی شمسی زاده - Physiology-pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Background and objective: Transient global cerebral ischemia leads to neuronal damage in the hippocampus and cerebral cortex which results in learning and memory impairment. Exercise preconditioning helps with neuroprotection against cerebral injuries induced by ischemia. The purpose of the present study was to investigate the effect of exercise preconditioning on tactile learning following global cerebral ischemia in rats. Materials and Methods: A total of ۵۰ male wistar rats weighing ۲۵۰-۳۰۰g were divided into ۵ experimental groups. Exercise was performed on a treadmill and animals ran with the speed of ۱۸ m/s for ۳۰ minutes, ۵ days per week for ۳ weeks. Ischemia was induced by a four-vessel occlusion (vertebral and common carotid arteries) method. Tactile memory was assessed using a novel object recognition task. Results: Frequency of visits to a familiar object increased in the ischemia group (۴۸ ± ۹.۴ Hz) compared to the control (۲۲.۸ ± ۲.۷ Hz). Also discrimination index decreased in the ischemia group (۳۹.۸ ± ۱.۶%) compared to the sham (۶۰.۲ ± ۲.۸%). Exercise preconditioning improved this index in the ischemic animals (۵۷.۳ ±۶.۶%). Conclusion: Transient cerebral ischemia can impair tactile learning and exercise preconditioning can prevent this deficit in the ischemic rats.

Keywords: Transient cerebral ischemia, Preconditioning, Male rat, Exercise, Tactile learning