The Effect of Hydroalcoholic Extract of Heracleum Persicum on Pentylenetetrazol _Induced Seizure in Mice
Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ZUMS-21-86_005
تاریخ نمایه سازی: 11 اردیبهشت 1400
Abstract:
Background and Objective: Epilepsy is the most common neurological disorder after stroke. The aim of the present study was to evaluate the effect of hydroalcoholic extract of Heracleum persicum on pentylenetetrazol (PTZ) - induced seizure in mice. Materials and Methods: In this study, ۳۰ male mice were divided into five groups. ۳۰ minutes after IP administration with different doses of extract (۷۵,۱۵۰, ۳۰۰, ۶۰۰mg/kg), PTZ (۸۰ mg/kg) was injected to animals and they were instantly transferred to a special cage. Consequently, the convulsive behaviors of the mice were recorded by a camera as long as ۲۰ minutes and the data were converted into seconds to be considered for analysis. Results: The results indicated that hydroalcoholic extract of Heracleum persicum has a significant effect on threshold tonic seizure in doses of ۱۵۰ mg/kg, ۳۰۰mg/kg and ۶۰۰ mg/kg. In clonic phase, threshold increased slightly with an increase in doses of extract. In tonic-clonic phase, threshold increase was significant only in doses of ۱۵۰ mg/kg and ۹۰۰ mg/kg. This extract significantly decreased seizure duration time both in tonic and tonic-clonic phases upon dose increasing. Conclusion: The results of the present study imply that injection of hydro-alcoholic extracts of Heracleum persicum led to anticonvulsant activity. This extract augmented the onset of different seizure phases while reduced duration of tonic and tonic-clonic phases.
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Authors
فاطمه سعیدی
Cellular and Molecular Research Center, Dept. of Physiology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
حسن اژدری زرمهری
Cellular and Molecular Research Center, Dept. of Physiology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
الهه ارمی
Cellular and Molecular Research Center, Dept. of Physiology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
بنیامین علی محمدی
Torbat-e-Heydarieh University of Medical Sciences, Torbat-e-Heydarieh, Iran