Changes in IGF Axis and Some Binding Proteins in Postmenopausal Women with Breast Cancer after ۱۵ Weeks of Combined Exercise Training

Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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JR_ZUMS-22-91_001

تاریخ نمایه سازی: 11 اردیبهشت 1400

Abstract:

Background and Objective: IGFs (Insulin-like growth factors) and some binding proteins can cause occurrence and recurrence of breast cancer. Since the role of combined exercise training on these factors is not clear, therefore, the aim of this study was to look at the changes of IGF axis and some binding proteins in postmenopausal women with breast cancer after ۱۵ weeks of combined exercise training. Materials and Methods: Twenty- nine women with breast cancer (۵۸.۲۷ ± ۶.۳۱ years) who underwent surgery, chemotherapy and radiation- therapy with current hormone therapy were divided into two groups of experimental and control. Subjects of the experimental group performed ۱۵ weeks of combined exercises including walking (۲ sessions per week) and resistance training (۲ sessions per week that differed from walking days). Data were analyzed by using ANCOVA (p≤ ۰.۰۵). Results: Combined exercise training had significant effect on IGF-۱ levels (P= ۰.۰۰۱), IGFB-۳ levels (P= ۰.۰۰۰) and IGF-۱: IGFB-۳ (P= ۰.۰۰۰) in postmenopausal women with breast cancer. After ۱۵ weeks, IGE -۱ reduced in the experimental group up to ۹ percent and IGFB-۳ increased by ۲۸ percent. On the other hand, exercise training had no significant effect on the IGFB-۱ (P= ۰.۶۵۲) in postmenopausal women with breast cancer. Conclusion: While the IGF axis factors and some binding proteins play an important role in breast cancer and its recurrence, it seems that changes in these factors through combined exercise training programs can delay its recurrence.

Keywords:

Keywords: Combined exercise training , Breast cancer , Postmenopausal women , IGF-۱ , IGFBP-۳

Authors

رضا نوری

Dept. of Sport Sciences, University of Tehran, Kish International Campus, Kish, Iran

بهاره محمودیه

Dept. of Sport Sciences, University of Tehran, Kish International Campus, Kish, Iran

ارسلان دمیرچی

Dept. of Sport Sciences, University of Guilan, Rasht, Iran

فرهاد رحمانینیا

Dept. of Sport Sciences, University of Guilan, Rasht, Iran

نادر رهنما

Dept. of Sport Sciences, University of Isfahan, Isfahan, Iran

حمید امامی

Dept. of Oncology, Isfahan University of Medical Sciences, Isfahan, Iran