Plasma ۲۵ (OH) Vitamin-D Level and Metabolic Syndrome Risk Factors among Physicians of Zanjan

Background and Objective: Previous studies indicate an inverse association of serum ۲۵-hydroxyvitamin-D level with obesity, metabolic syndrome and cardiovascular events. This study was aimed to assess metabolic syndrome correlation with serum Vit-D levels of physicians in Zanjan city (Iran). Materials and Methods: In an analytical cross-sectional study, a total of ۱۰۸ physicians were selected and their ۲۵-hydroxyvitamin D status, fasting blood glucose, triglyceride and HDL were assessed using venous blood. Metabolic syndrome was defined based on ATPIII criteria. Data was analyzed using SPSS software. Results: The mean serum ۲۵(OH) D concentration was ۲۳.۴۰±۲۳.۷۲ ng/ml and its median level was ۱۷.۶۵ ng/ml. ۲۵ (OH) D concentrations <۲۰ ng/ml was observed in ۶۲% of the participants. The prevalence of Metabolic Syndrome for the whole sample was ۲۱.۲%. The most prevalent components of metabolic syndrome were hypertriglyceridemia and low HDL with a prevalence of ۵۵.۶% and ۳۸%, respectively. Significant correlative difference was found between serum ۲۵(OH) D levels and triglyceride (P = ۰.۰۰۹). Conclusion: The prevalence of vitamin D deficiency and metabolic syndrome among physicians in Zanjan was lower than general population. A significant association between serum levels of Vitamin D and triglyceride was detected, which may be due to higher BMI. References ۱- Hoseinnejad A, Maghbuli ZH, Mirzaie KH, Karimi F, Larijani B. Relation of vitamin D۳ level with metabolic syndrome among Iranian adult populations. Iran J Diabetes Lipid. ۲۰۰۹ ۹: ۳۸۳-۹. ۲- Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. executive summary of the third report of the national cholesterol education program (NCEP) JAMA. ۲۰۰۱ ۲۸۵-۹۷. ۳- Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nut. ۲۰۰۴ ۷۹: ۸۲۰-۵. ۴- Bonakdaran S, Varasteh A, Khajeh-Dalouie M. Serum ۲۵ hydroxy vitamin D۳ and laboratory risk markers of cardiovascular diseases in type ۲ diabetic patients. Iran J Endocrin Metab. ۲۰۱۰ ۵۰۴-۹. ۵- Chagas C, Borges M, Rogero L. Focus on vitamin D, inflammation and type ۲ diabetes. J Nutrients. ۲۰۱۲ ۴: ۵۲-۶۷. ۶- Tohru Funahashi,Yuji Matsuzawa, Shinji Kihara. Adiponectin as a potential key player in metabolic syndrome insights into atherosclerosis, diabetes and cancer. International Congress Series۱۲۶۲ ۲۰۰۴ ۳۶۸-۷۱ ۷- Wang C, Pereira R, Hosoka P, et al. Association between ۲۵-hydroxyvitamin D and adiponectin levels in hypertensive subjects. Eur J Endocrinol. ۲۰۱۱ ۱۶۴: ۹۹۵-۱۰۰۲. ۸- Chacko S, Song Y, Manson J, et al. Serum ۲۵-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women. The Am J Clin Nut. ۲۰۱۱ ۹۴ ۲۰۹-۱۷. ۹- Ziaee A, Hashemipoor S, Karimzadeh T, Jalalpoor A, Javadi A. Relation of vitamin D۳ Serum level with metabolic syndrome indices among patients with diabetes and non-diabetic individuals. J Ardabil Univ Med Sci. ۲۰۱۲ ۱۲: ۱۴۹-۵۶. ۱۰- Yilmaz H, Kaya M, Sahin M, Delibasi T. Is vitamin D status a predictor glycaemic regulation and cardiac complication in type ۲ diabetes mellitus patients?. J Diabetes Metab Clin Res Rev. ۲۰۱۲ ۲۵۳: ۳۵۰-۴. ۱۱- Sharifi F, Mousavinasab N, Saeini M, Dinmohammadi M. Prevalence of metabolic syndrome in an adult urban population of the west of iran. Expert Diabetes Res. ۲۰۰۹ ۱۴۰-۵. ۱۲- Hurskainen AR, Virtanen JK, Tuomainen TP, Nurmi T, Voutilainen S. Association of serum ۲۵-hydroxyvitamin D with type ۲ diabetes and markers of insulin resistance in a general older population in Finland. J Diabetes Metab Res Rev. ۲۰۱۲ ۲۸ ۴۱۸-۲۳. ۱۳- Park HY, Lim YH, Kim JH, Bae S, Oh SY, Hong YC. Association of serum ۲۵-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis.journal of Korean medical science. ۲۰۱۲ ۲۷ ۶۵۳-۶۶۰. ۱۴- Ford E, Ajani U, Mcguire L, Liu S. Concentrations of serum vitamin d and the metabolic syndrome among U.S. adults. J Diabetes care. ۲۰۰۵ ۲۸ ۱۲۲۸-۳۰. ۱۵- Salekzamani S, Neyestani TR, Alavi-Majd H, et al. Is vitamin D status a determining factor for metabolic syndrome? J Diabetes Metab Obes. ۲۰۱۱ ۴ ۲۰۵-۱۲.

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Key words: Metabolic syndrome , Vitamin D , Obesity , Physicians