مهدی ترابی - Dept. of Emergency Medicine, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
میترا ثمره فکری - Pulmonology Cardiovascular Research Center, Institute of Basic and clinical physiology sciences, Kerman University of Medical Sciences, Kerman, Iran
سارا عزیزی شول - Dept. of Emergency Medicine, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
احمد نقیب زاده - Dept. Epidemiology, Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
شیوا معین الدینی - Dept. of Emergency Medicine, Faculty of Medicine, Rafsanjan University of Medical Sciences, Kerman, Iran

Background and Objective: Chronic Obstructive Pulmonary Disease (COPD) is a chronic obstructive and irreversible disease which has a high mortality and morbidity rate. Systemic inflammation and the thrombotic process can influence the prognosis of these patients. The objectives of this study were to evaluate prognostic effects of CBC indices (WBC, PMN, MPV, RDW), forced expiratory volume-one second (FEV۱) and mean Pulmonary Artery Pressure (mPAP) in the prognosis of COPD patients with acute exacerbation of the disease. Material and Methods: This cross-sectional study was performed on exacerbated COPD patients who were admitted to the emergency department, Afzalipour Hospital, Kerman, Iran during ۲۰۱۶-۲۰۱۷. For all the patients, CBC was assessed as they arrived then Pulmonary Function Test and echocardiography were conducted.  In order to create the final model, we employed multivariate regression analysis. Results: A total of ۱۰۷۸ patients were enrolled during one year, of which ۵۸.۳% were male. In multivariate analysis, White blood cells (WBC), Polymorphonuclear leukocytes (PMN), Mean platelet volume (MPV), Red Cell Distribution Width (RDW), FEV۱ and mPAP were the six variables which are independently associated with hospital mortality and ICU admission. Sensitivity, specificity and area under the curve for these six variables model were ۷۸.۵, ۹۲ and ۸۶% respectively. Conclusion: Since the inflammatory and thrombotic events are influential in the prognosis of COPD patients, it may be possible to predict patients outcome with CBC related indices (WBC, PMN, MPV and RDW), although other important risk factors such as pulmonary hypertension and FEV۱ decrease should be considered as well.

COPD, Mean platelet volume, Red Cell Distribution Width, Hospital mortality