مهران محسنی - Dept .of Food and Drug Control, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
کریم داداشی - Dept .of Biotechnology and Nanotechnology, Faculty of Medicine, Student Research Committee, Zanjan University of Medical Sciences, Zanjan, Iran
اعظم حیدری - Dept .of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Background and Objective: With the industrialization of nanotechnology and increase in application of nanoparticles in modern technology, carrying out research on nanoparticles and their effects on health is necessary. So, this study was aimed to assess acute toxicity of molybdenum nanoparticles on serum biochemical function of kidney in rat. Materials and Methods: In this experimental study, ۲۴ male rats were randomly divided into four groups of six: a control group and tree treatment groups. The control group received ۱ ml distilled water and the treatment groups received intraperitoneal injection of ۵, ۱۰ and ۱۵ mg/kg of molybdenum nanoparticles of ۱۰ nm daily for ۲۸ days. After the last dose, blood samples were taken from all groups and levels of Blood Urea Nitrogen (BUN), creatinine, total protein and albumin were measured and then the groups were compared. Results: The serum levels of BUN and creatinine in the group receiving ۱۵ mg/kg dose decreased significantly compared to the control group (P<۰.۰۵). The serum albumin level in the groups receiving ۱۰ and ۱۵ mg/kg doses showed significant decrease compared to the control group (P<۰.۰۵). The serum total protein level in the groups receiving ۵, ۱۰ and ۱۵ mg/kg doses showed significant decrease compared to the control group (P<۰.۰۵). Conclusion: The results of this study showed that molybdenum nanoparticles of ۱۰ nm at these concentrations decrease creatinine and BUN levels of serum.

Key word: Molybdenum nanoparticles, Blood Urea Nitrogen, Creatinine, Toxicity