Prevalence and Antibiotic Resistance Patterns of Isolated Enterococci from Hospitals of Zanjan City
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ZUMS-23-101_004
تاریخ نمایه سازی: 11 اردیبهشت 1400
Abstract:
Background and Objective: Enterococci lead to many problems in terms of treatment failure and mortality in patients especially due to antibacterial resistance. Identification of antibiotic resistance in community is of extreme importance to prevent failures particularly in the treatment of infections. Therefore, this study intended to screen antibiotic-resistant enterococci samples from patients.
Materials and Methods: Samples were collected from feces and blood of patients hospitalized over a period of ۹ months from July ۲۰۱۳ to March ۲۰۱۴ in Vali-e Asr and Mousavi hospitals. Diagnostic tests such as growth in the presence of bile esculin agar and NaCl ۶.۵% as well as catalase and Gram staining were performed to verify the samples. Agar disk diffusion method for antibiotic susceptibility testing and microtitre plate assay was performed to evaluate the MIC of vancomycin.
Results: Among the tested antibiotics, ciprofloxacin showed the highest and teicoplanin as well as vancomycin exhibited the least antibiotic resistance. Interestingly, vancomycin minimum inhibitory concentration was determined ۵ to ۵۰ &mug/ml.
Conclusion: In our study, isolated enterococci from the hospitalized patients showed relatively high resistance to majority of antibiotics. Meanwhile, antibiotic resistance to teicoplanin and vancomycin were acceptable in comparison to other similar studies.
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Authors
مریم حسن
Pharmaceutical Biotechnology Research Center, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
حسین جهانگیری
Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
کورش کمالی
Dept. of Food Safety & Hygiene, Faculty of Paramedical & Health Sciences, Zanjan University of Medical Sciences, Zanjan, Iran
زویا هژبری
Dept. of Microbiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
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