مهسا حسینی صنعتی - Dept. of Physical Therapy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
گیتی ترکمان - Dept. of Physical Therapy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
مهدی هدایتی - Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
منوچهر ایرانپرور علمداری - Dept .of Endocrinology, Faculty Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Background and Objective: Diabetic foot ulcer as one of the most common complications of diabetes mellitus is known to be resistant to conventional treatment of wound healing. The objective of this study was to evaluate the efficacy of low level laser therapy with Ga-As laser, ۹۰۴ nm, in foot ulcer healing of type ۲diabetic patients. Materials and Methods: ۲۷ patients with Type ۲ diabetes mellitus suffering from Wagner Grade II ischemic foot ulcers were randomly divided into two groups: Ga-As laser (n=۱۵) and placebo (n=۱۲). In the laser therapy group, Ga-As, (۲ j/cm۲, ۹۰mW) was applied while in the placebo group laser probe was set similar to the laser group,  but the power was off. Conventional treatment after laser therapy was done for both groups in a similar vein, i.e., three times a week for twelve sessions. Wound surface area and temperature around the wound (before and after therapy) in the ۱st, ۶th and ۱۲th sessions and Ankle Brachial Index (ABI) in the۱st and ۱۲th sessions were recorded. Results: Throughout the ۶th and ۱۲th sessions, reduction in wound surface percentatage in comparison with baseline was significantly (P<۰.۰۵) higher in the laser group (۴۳.۹۸±۶.۳۶, ۷۲.۰۸±۷.۲۲ respectively) than the placebo group (۶.۴۸±۷.۹۸, ۱۲.۶۹±۹.۰۵ respectively), but the skin temperature and ABI values did not show any significant difference. Conclusion: Ga-As laser using photochemical and non-thermal mechanisms may be effective on the acceleration of diabetic chronic foot ulcer closure.

Keywords: Gallium-Arsenide Laser, Diabetic foot ulcer, Wound closure, Ankle brachial index