محمدعلی زمانی - Dept. of Pediatrics, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
سیدمحمدکاظم نوربخش - Dept.of Pediatrics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
محمود رفیعیان - Herbal Medicine Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
زهرا کیوانی هفشجانی - Dept. of Nursing, Shahrekord University of Medical Sciences, Shahrekord, Iran.
سعید حیدری سورشجانی - Dept. of Research and Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background and Objective: Acute bronchiolitis is one of the most common reasons for inflammation, small airways obstruction, and lower respiratory tract infection in infancy. Owing that there has been no study on the efficacy of hypersaline ۳% in the treatment of acute bronchiolitis in Iran, the present study was undertaken to deal with this issue. Materials and Methods: This double-blinded clinical trial was carried out in Hajar Hospital of Shahrekord in ۲۰۱۳-۲۰۱۴. ۷۰ patients under ۲ years of age with bronchiolitis were assigned to two groups of ۳۵ each. The first group received nebulized Ventolin while the second group was given nebulized hypersaline ۳% three times a day. Subsequent to these administrations, recovery duration was compared in both groups. Results: The mean and standard deviation of recovery duration in the Ventolin group was ۴.۱۴±۰.۹ days and in the hypersaline ۳% group was ۳.۰۶±۰.۶ days. T-test and mean recovery duration was significantly lower in the hypersaline ۳% group (P<۰.۰۰۱). Conclusion: Nebulizer hypersaline ۳% had a better therapeutic effect than Ventolin in the treatment of acute bronchiolitis. Therefore, the use of this drug, rather than Ventolin, is recommended for the treatment of acute bronchiolitis in children under two years of age.

Keywords: Bronchiolitis, Ventolin, Hypertonic Saline solution