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Prolifration and Anti-Apoptotic Effect of Hydroethanolic Extract of Lavandula officinalis on Rat Neural Stem Cells

Publish place: Journal of Advances in Medical and Biomedical Research، Vol: 24، Issue: 105
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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لینک ثابت به این Paper:
https://civilica.com/doc/1191702

شناسه ملی سند علمی:

JR_ZUMS-24-105_005

تاریخ نمایه سازی: 11 اردیبهشت 1400

Abstract:

Background and Objective: Nowadays, extensive research is carried out on the effect of plant extracts on variety of disorders. In this study, the effect of hydroethanolic extract of Lavandula officinalis on proliferation of neural stem cells as well as its anti-apoptotic properties was assessed. Materials and Methods: Neural stem cells were isolated from hippocampus of neonatal rat brain. To determine the optimal concentration of Lavandula officinalis extract, isolated neural stem cells were treated with ۲۰۰, ۴۰۰, ۶۰۰, ۸۰۰ and ۱۰۰۰ µg/ml of concentrate for ۴۸ h. Then cell proliferation rate was evaluated via MTT assay. Meanwhile, the anti-apoptotic property of Lavandula officinalis extract was evaluated using TUNEL assay method.  Results: The results of this study showed a significant difference in cell proliferative and anti-apoptotic property of Lavandula officinalis extract on neural stem cells comparing to the control group. Conclusion: The hydroethanolic extract of Lavandula officinalis can be effective on proliferation elevation  and apoptosis reduction  in rat neural stem cells.

Keywords:

Keywords: Cell proliferation , Lavandula officinalis , Neural stem cells , Apoptosis , Rat

Authors

علیرضا عبدانی پور

Dept. of Anatomy, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

رضا نجات بخش

Dept. of Anatomy, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

ایرج جعفری انارکولی

Dept. of Anatomy, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

مهرداد قربانلو

Dept. of Anatomy, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

علی نیک فر

Dept. of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

امبر نوریان

Young Researchers and Elite Club, Islamic Azad University Ardabil Branch, Ardabil, Iran.

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