Impact of Peganum harmala Oral Capsule on Alleviating Nocturia in Men with Benign Prostatic Hyperplasia (BPH)
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ZUMS-25-113_004
تاریخ نمایه سازی: 11 اردیبهشت 1400
Abstract:
Background and Objective: Nocturia is considered as the most common symptom in men with benign prostatic hyperplasia. This study aimed to determine the effects of Peganum harmala seeds in comparison with tamsulosin in alleviating symptoms in patients with benign prostatic hyperplasia.
Materials and Methods: In this single blind clinical trial study, ۹۰ patients diagnosed with BPH and LUTS (lower urinary tract symptoms) based on the international prostate standard survey (IPSS), were divided into three groups. The first group received oral capsules of Peganum harmala, the second group was administered tamsulosin with oral Peganum harmala seeds while the third group received tamsulosin. All groups were evaluated after ۴ weeks. The data were analyzed via SPSS ۲۲ using descriptive, Kruskal-Wallis, Wilcoxon and Mann-Whitney tests.
Results: The results showed that the difference between mean IPSS scores was significant after the intervention (P = ۰.۰۰۱). The mean IPSS scores of the three groups were significantly different
(P = ۰.۰۰۱) (the first group ۴۱.۹± ۵.۳, the second group ۲۱.۰ ± ۴.۴ and the third group ۱۶.۵ ± ۳.۷). Patients in the second group had the lowest average on most indicators of IPSS but the difference was only significant in urinary frequency, nocturia and intermittency (P <۰.۰۵).
Conclusions: The results of this study indicate that Peganum harmala seeds may be useful in reducing nocturia symptoms in patients with benign prostatic hyperplasia.
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Authors
مجید شیرانی
Dept. of Surgery, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
فروزان گنجی
Dept. of Community Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
زهرا کیوانی هفشجانی
Dept.of Nursing, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran.
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