Crocin Reduces Oxidative Stress Produced by Busulfan Administration on Fertility of Male Rats
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ZUMS-27-125_004
تاریخ نمایه سازی: 11 اردیبهشت 1400
Abstract:
Background & Objective: Busulfan (BUS) as a drug for cancer treatment can produce free radicals. Crocin (CRO) is a potent antioxidant with beneficial effects. This study was designed to evaluate the effects of CRO against BUS-related damages to the male rats reproductive parameters.
Materials & Methods: Forty-eight male rats were randomly assigned into ۸ groups; Group ۱ (normal control group) received normal saline; Group ۲ (BUS control group) received ۱۰ mg/kg/body weight (b.w.) of BUS; Group ۳-۵ (CRO groups) received ۱۲.۵, ۲۵.۰, ۵۰.۰ mg/kg/b.w. of CRO, respectively; Group ۶-۸ (BUS + CRO groups) received BUS + CRO. Treatments were administered daily by intraperitoneal injection in a five-week period. The sperm parameters, testis malondialdehyde (MDA), total antioxidant capacity (TAC), testosterone level, and germinal layer height were evaluated histologically and analyzed statistically.
Results: All parameters reduced significantly in the BUS control group compared to the normal control group (P<۰.۰۱) except the MDA level (which increased). The CRO and CRO + BUS treatments in all doses increased whole parameters significantly compared to the BUS control group (P<۰.۰۱) except MDA level (which decreased). No significant modifications were observed in all CRO groups compared to the normal control group (P>۰.۰۵).
Conclusion: It seems that CRO could increase the quality of spermatozoa and improves BUS -induced adverse effects on male fertility parameters.
Authors
Shiva Roshankhah
Dept. of Anatomical Sciences, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Amir Abdolmaleki
Dept. of Anatomical Sciences, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Cyrus Jalili
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Mohammad Reza Salahshoor
Dept. of Anatomical Sciences, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
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