Correlation of Plasma RBP۴-to-Vitamin A Ratio with Severity of Diabetic Retinopathy

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نوع سند: مقاله ژورنالی
زبان: English
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JR_ZUMS-28-129_001

تاریخ نمایه سازی: 11 اردیبهشت 1400

Abstract:

Background & Objective: Diabetic retinopathy (DR) is a common microvascular complication of type ۲ diabetes mellitus (T۲DM) and the leading cause of vision loss in working-age adults. Vitamin A (retinol) has a role in the mechanism of vision process and retinol binding protein-۴ (RBP۴), is a carrier of vitamin A, and as an adipokine may be associated with increased risk for insulin resistance and DR. This case-control study was aimed to determine and analyze plasma RBP۴-to-vitamin A ratio in relation with terms of DR severity. Materials & Methods: In the present analytical cross-sectional study, ۵۱ T۲DM patients, aged ۴۸-۷۳ years old, were enrolled from those attending to the Ophthalmology Center of Vali-e Asr Hospital, Zanjan, Iran. Patients were categorized as non-retinopathy diabetic patients (NRDP) without any eye problem, those with mild non-proliferative DR (mild NPDR) (n=۱۲), those with severe non-proliferative diabetic retinopathy (severe NPDR) (n=۱۲), and those with proliferative DR (PDR) (n=۱۲); a control group (n=۱۵) was also considered. Anthropometric parameters, BMI, and WHR were determined and blood sample weas taken from each participant after overnight fasting (۱۲-۱۴h) to measure their biochemical parameters. Serum RBP۴ and vitamin A levels were measured via ELISA and C۱۸ reverse-phase HPLC methods, respectively. Results: Plasma RBP۴ concentration was significantly higher in three different stages of DR than that of the control group suffering from diabetes (۷۷.۰±۱۱.۰, ۸۱.۷±۱۰.۹ and ۸۸.۳±۱۱.۹ vs. ۷۱.۴±۱۲.۳, respectively; P=۰.۰۰۴). The ratio of plasma RBP۴-to-retinol in DR groups was found to be significantly higher than that in the control group suffering from diabetes (۰.۲۱±۰.۰۶, ۰.۲۷±۰.۱۲ and ۰.۲۸±۰.۰۷ vs. ۰.۱۶±۰.۱۴, respectively; P=۰.۰۰۱). Conclusion: Higher plasma RBP۴-to-vitamin A ratio was related to DR severity. Further experimental studies with larger scales are recommended.

Authors

Hadi Rostamkhani

Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Arezo Karimimoghaddam

Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Jalal Hejazi

Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Hossein Chiti

Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Ali Awsat Mellati

Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

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