Mohammad Rashidi - Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
Amjad Ahmadi - Dept. of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
Rashid Ramazanzadeh - Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
Bijan Noori - Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
Faranak Shafiee - Dept. of Pediatric Dentistry, Faculty of Dentistry, Kurdistan University of Medical Sciences, Sanandaj, Iran

Background and Objectives: Candida species is one of the commensal microorganisms and a member of the oral cavity normal flora. In addition, Candida albicans is a microbiologic member of the oral cavity in children with dental caries. Currently, use of probiotics as a new biologic technique has attracted attention in order to prevent and control diseases. Enterococcus durans has shown useful antioxidative properties and antibacterial and probiotic characteristics. The aim of this study was to evaluate the effect of probiotic Enterococcus durans on adhesion of Candida albicans in in vitro.   Materials and Methods: In this in vitro study, the standard strain bacteria of probiotic E. durans (ATCC ۶۰۵۶) and Candida albicans (PTCC۵۰۲۷) and ۱۰ clinical samples of Candida albicans is provided. The adhesive inhibition of Candida albicans via microtiter plate was tested.  Data were analyzed with repeated measure model. Statistical significance was set at P<۰.۰۱ Results: This study showed that, Mean OD۶۲۰ nm were in range of ۰.۴۵ to ۰.۴۹ and for OD۴۹۰ nm were ۰.۳۳. Therefore, in presence of the probiotic strain, the biofilm of Candida albicans adhesion were reduced. Conclusion: The first step in infection process is attachment and the adhesion                  of Candida albicans can be prohibited by use of probiotic such as E. durans.

Probiotic, Enterococcus, Candida albicans