Chronic Caffeine Ingestion Down-Regulates Liver and Visceral Adipose Tissue Inflammatory Gene Expression in High-Fat Diet-Induced Obesity

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
View: 265

This Paper With 8 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_ZUMS-29-135_001

تاریخ نمایه سازی: 11 اردیبهشت 1400

Abstract:

Background and Objective: Beverages containing caffeine have an anti-obesity function. Reduction of visceral adipose tissue (VAT) inflammation is considered an important strategy to ameliorate obesity compilations such as insulin resistance. This study aimed to investigate the effect of ۸-week caffeine supplementation on the messenger RNA (mRNA) expression of fetuin-A (FetA) in the liver and nuclear factor kappa B (Nf-κb) and toll-like receptor ۴ (Tlr۴) in the VAT of rats with a high-fat diet (HFD). Methods: A total of ۴۰ male Wistar rats were randomly divided into control, caffeine, HFD, and HFD+caffeine supplement groups. After ۲ weeks of acclimatization, the rats were randomly fed with HFD (۴۶% fat) and a normal diet (۵% fat) for ۸ weeks. The rats in the caffeine groups were gavaged with ۶ mg of the caffeine solution per kg of body weight. FetA mRNA of the liver, Nf-κb, and Tlr۴ mRNA of VAT were determined using real-time polymerase chain reaction (PCR). Results: The results indicated that FetA mRNA expression and weight gain in HFD+caffeine were significantly reduced compared to the other groups. Nf-κb mRNA expression was significantly higher in the HFD group than in the caffeine groups. No statistically significant differences were found in Tlr۴ mRNA expression between the groups. Conclusion: These findings suggest that consuming caffeine can prevent HFD-induced liver and adipose tissue (AT) inflammation.

Authors

Seyed Dara Hosseini

Dept. of Exercise Physiology, University of Kurdistan, Sanandaj, Iran

Mohammad Rahman Rahimi

Dept. of Exercise Physiology, University of Kurdistan, Sanandaj, Iran

Mehdi Abbaspoor

Dept. of Physical Education and Sport Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Sell H, Habich C, Eckel J. Adaptive immunity in obesity ...
  • Engin AB. Adipocyte-macrophage cross-talk in obesity. Obesity and Lipotoxicity: Springer; ...
  • Cochet F, Peri F. The role of carbohydrates in the ...
  • Pal D, Dasgupta S, Kundu R, et al. Fetuin-A acts ...
  • Trepanowski J, Mey J, Varady K. Fetuin-A: a novel link ...
  • Chatterjee P, Seal S, Mukherjee S, et al. Adipocyte fetuin-A ...
  • Cechella JL, Leite MR, Dobrachinski F, et al. Moderate swimming ...
  • Ramakers BP, Riksen NP, van den Broek P, et al. ...
  • Yamauchi R, Kobayashi M, Matsuda Y, et al. Coffee and ...
  • Choi KM, Han KA, Ahn HJ, et al. The effects ...
  • Öner-İyidoğan Y, Koçak H, Seyidhanoğlu M, et al. Curcumin prevents ...
  • Köroğlu ÖA, MacFarlane PM, Balan KV, et al. Anti-inflammatory effect ...
  • Liu CW, Tsai HC, Huang CC, et al. Effects and ...
  • Noeman SA, Hamooda HE, Baalash AA. Biochemical study of oxidative ...
  • Kobayashi-Hattori K, Mogi A, Matsumoto Y, Takita T. Effect of ...
  • Banaeifar AA, Gorzi A, Hedayati M, Nabiollahi Z, Neda RM, ...
  • Gentile AM, Lhamyani S, Coín-Aragüez L, et al. RPL13A and ...
  • Rebouças EdL, Costa JJdN, Passos MJ, Passos JRdS, Hurk Rvd, ...
  • Kolahdouzi S, Talebi-Garakani E, Hamidian G, Safarzade A. Exercise training ...
  • Yang Y, Wang J. The functional analysis of MicroRNAs involved ...
  • Dwivedi DK, Kumar D, Kwatra M, et al. Voluntary alcohol ...
  • Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling ...
  • Zhao W, Ma L, Cai C, Gong X. Caffeine inhibits ...
  • Sheng Y, Li F, Qin Z. TNF receptor 2 makes ...
  • Prager P, Hollborn M, Steffen A, Wiedemann P, Kohen L, ...
  • Thakkinstian A, Chailurkit L, Warodomwichit D, et al. Causal relationship ...
  • Lin X, Braymer H, Bray G, York D. Differential expression ...
  • Rivera-Oliver M, Díaz-Ríos M. Using caffeine and other adenosine receptor ...
  • Tauler P, Martinez S, Martinez P, Lozano L, Moreno C, ...
  • Haskó G, Cronstein B. Methylxanthines and inflammatory cells. Methylxanthines: Springer; ...
  • Wedick NM, Brennan AM, Sun Q, Hu FB, Mantzoros CS, ...
  • Dangol M, Kim S, Li CG, et al. Anti-obesity effect ...
  • Pal D, Dasgupta S, Kundu R, et al. Fetuin-A acts ...
  • Fletcher DK, Bishop N. Caffeine ingestion and antigen‐stimulated human lymphocyte ...
  • Fletcher DK, Bishop NC. Effect of a single and repeated ...
  • نمایش کامل مراجع