Claire Farrell - Department of Medical Imaging, Medical Radiations and Nuclear Medicine, Eastern Health, Victoria, Australia
Jo-Anne Pinson - Department of Medical Imaging, Monash Health, Peninsula Health, Victoria, Australia
Amy Dennett - School of Allied Health, Human Services and Sport, La Trobe University, Allied Health Clinical Research Office, Eastern Health, Victoria, Australia

Myocardial perfusion imaging is a non-invasive procedure that plays an integral role in the diagnosis and management of coronary artery disease. With the routine use of computerised tomography attenuation correction (CTAC) in myocardial perfusion imaging still under debate, the aim of this review was to determine the impact of CTAC on image quality in myocardial perfusion imaging. Medline, Embase and CINAHL were searched from the earliest available time until August ۲۰۱۹. Methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies version ۲. Details pertaining to image quality and diagnostic accuracy were analysed, and results summarised descriptively. Three studies with ‘unclear’ risk of bias and low applicability concerns (۱۰۰۲ participants) from a yield of ۲۷۲۵ articles were identified. Two studies demonstrated an increase in image quality, and one study found no difference in image quality when using CTAC compared to no attenuation correction. Benefits of CTAC for improving image quality remain unclear. Given the potential exposure risk with the addition of CTAC, patient and clinician factors should inform decision making for use of CTAC in myocardial perfusion imaging for coronary artery disease.

Coronary Artery Disease, Nuclear Medicine, Attenuation Correction, computerised tomography